\u767c\u708e\u6027\u8178\u75c5Inflammatory Bowel Disease\uff08IBD\uff09\u53ef\u5206\u70ba\u5169\u7a2e\uff0c\u6f70\u760d\u6027\u5927\u8178\u708e Ulcerative colitis \u548c \u514b\u9686\u6c0f\u75c7Crohn’s disease\uff08CD\uff09\u3002UC\u60a3\u8005\u7684\u8178\u9053\u8178\u58c1\u8868\u9762\u4e0a\u6703\u5f62\u6210\u5fae\u5c0f\u7684\u6f70\u760d\uff0c\u9019\u4e9b\u6f70\u760d\u53ef\u80fd\u6703\u5728\u8178\u9053\u5167\u51fa\u8840\u6216\u6d41\u81bf\u3002\u60a3\u75c5\u521d\u671f\uff0c\u901a\u5e38\u65bc\u76f4\u8178\u548c\u4e0b\u7d50\u8178\u767c\u708e\uff0c\u4f46\u708e\u75c7\u53ef\u80fd\u6703\u5f71\u97ff\u6574\u689d\u7d50\u8178\u3002UC\u60a3\u8005\u7684\u6574\u689d\u5927\u8178\uff08\u76f4\u8178\u81f3\u7d50\u8178\uff09\u5167\u8178\u58c1\u90fd\u6703\u767c\u708e\u53ca\u5f62\u6210\u6f70\u760d\u3002\u800c\u708e\u75c7\u662f\u7576\u8eab\u9ad4\u9762\u5c0d\u53d7\u5275\u50b7\u6216\u523a\u6fc0\u7684\u53cd\u61c9\uff0c\u4e26\u53ef\u5c0e\u81f4\u767c\u7d05\uff0c\u816b\u8139\u548c\u75bc\u75db\u3002<\/p>\n
\u5982\u679c\u60a3\u8005\u60a3\u6709\u809a\u7009\u800c\u7cde\u4fbf\u4e2d\u5e36\u8840\u53ca\u8179\u90e8\u75bc\u75db\uff0c\u91ab\u751f\u4fbf\u6703\u521d\u6b65\u8a3a\u65b7\u70ba\u6f70\u760d\u6027\u5927\u8178\u708e\uff0c\u70ba\u78ba\u5b9a\u8a3a\u65b7\u60a3\u8005\u5c07\u88ab\u8981\u6c42\u9032\u884c\u8840\u6db2\u6aa2\u67e5\u3002\u800c\u4e14\u9700\u8981\u6642\u60a3\u8005\u5c07\u6703\u9032\u884c\u5927\u8178\u93e1\u6aa2\u67e5\u53ca\u6d3b\u7d44\u7e54\u5316\u9a57\u4f86\u78ba\u8a3a\u3002<\/p>\n
\u767c\u708e\u6027\u8178\u75c5\uff08IBD\uff09\u60a3\u8005\u7684\u8178\u9053\u83cc\u7fa4\u6703\u6709\u6301\u7e8c\u6027\u7684\u8b8a\u5316\u3002\u7576\u8178\u9053\u83cc\u7fa4\u9054\u5230\u6700\u9ad8\u6c34\u5e73\uff0c\u9019\u6a23\u6703\u4f7f\u8178\u9053\u83cc\u7fa4\u591a\u6a23\u6027\u4e0b\u964d\uff0c\u8b8a\u6210\u5931\u8861\u72c0\u614b\uff08\u7a31\u70ba\u83cc\u7fa4\u5931\u8abfdysbiosis\uff09\u3002HMT\u6cbb\u7642UC\u5df2\u7d93\u5728\u4e00\u4e9b\u7814\u4e2d\u7522\u751f\u4e86\u6b63\u9762\u7684\u7d50\u679c\u3002\u5728\u4e00\u4efd\u7684\u7814\u7a76\u5831\u544a\u4e2d\uff0c555\u540dUC\u60a3\u8005\u4e2d\u6709201\u4f4d\uff08\u7d0436\uff05\uff09\u63a5\u53d7HMT\u6cbb\u7642\u5f8c\u7372\u5f97\u81e8\u5e8a\u4e0a\u7684\u8212\u7de9\uff0c\u800c\u672a\u80fd\u89c0\u5bdf\u5230\u6709\u660e\u986f\u7684\u526f\u4f5c\u7528\u3002\u57282017\u5e74\uff0c\u6fb3\u6d32\u767c\u5e03\u4e86\u4e00\u9805\u6700\u65b0\u7684\u7814\u7a76\uff0c\u7814\u7a76\u4e2d\u6307\u51faUC\u60a3\u8005\u63a5\u53d7FMT\u4e2d\uff0c\u670927\uff05\u7684\u60a3\u8005\u53d7\u76ca\uff0c\u800c \u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u53ea\u670911\uff05\u53d7\u76ca1\u3002<\/p>\n
\u4e9e\u6d32\u76ca\u83cc\u4e2d\u5fc3\u8207\u672c\u5730\u77e5\u540d\u80c3\u8178\u75c5\u5c08\u5bb6\u7dca\u5bc6\u5408\u4f5c\u3002\u6211\u5011\u7684HMT\u6cbb\u7642\u7a0b\u5e8f\u662f\u7531\u6211\u5011\u7684\u8178\u80c3\u79d1\u5c08\u5bb6\u9867\u554f\u7684\u5efa\u8b70\u53ca\u56e0\u500b\u4eba\u9700\u8981\u800c\u8a02\u7acb\u51fa\u4f86\u3002
\n\u8a72\u8a08\u5283\u662f\u901a\u904e\u6062\u5fa9\u8178\u9053\u5167\u5fae\u751f\u7269\u83cc\u7fa4\u7684\u5e73\u8861\uff0c\u4f86\u5e6b\u52a9\u60a8\u7de9\u89e3\u4e0d\u9069\u7684\u75c7\u72c0\uff0c\u7531\u6b64\u7372\u5f97\u9577\u671f\u76ca\u8655\u3002<\/p>\n
\u4eba\u985e\u83cc\u7fa4\u79fb\u690d\u7642\u6cd5\uff08HMT\uff09\u4e3b\u8981\u76ee\u7684\u662f\u91cd\u65b0\u5e73\u8861\u60a3\u8005\u8178\u9053\u4e2d\u7684\u5fae\u751f\u7269\u7fa4\uff0c\u9019\u53ef\u4ee5\u8212\u7de9\u60a3\u8005\u8178\u9053\u7684\u76f8\u95dc\u75c7\u72c0\u3002\u6f70\u760d\u6027\u7d50\u8178\u708e\u662f\u4e00\u7a2e\u91ab\u5b78\u75be\u75c5\uff0c\u6cbb\u7642\u5fc5\u9808\u8981\u5728\u91ab\u751f\u7684\u76e3\u7763\u4e0b\u9032\u884c\u3002\u5982\u6709\u4efb\u4f55\u6709\u95dc\u85e5\u7269\u4e0a\u6216\u8655\u65b9\u4e0a\u7684\u554f\u984c\u8acb\u8aee\u8a62\u4f60\u5bb6\u5ead\u91ab\u751f\u3002\u56e0\u6b64\uff0c\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7642\u4e4b\u524d\uff0c\u5fc5\u9808\u8981\u7372\u5f97\u91ab\u751f\u7c3d\u767c\u7684\u8f49\u4ecb\u4fe1\u3002<\/p>\n
Your doctor may ask to have further blood tests to test if you are anaemic and whether your illness has caused the level of protein to fall. In general, the greater the degree of anaemia and the lower the protein level, the more severe the inflammation is likely to be. Doctors also use special blood tests called ESR and CRP to give a measure of the degree of inflammation. You may be asked to give small samples of your bowel motions, to measure levels of faecal calprotectin, which is a marker of inflammation and to be sure there are no signs of any bowel infection.<\/p>\n
In UC patients gut microbiome shifts, often these shifts include fewer bacteria in the Bacteroides and Lachnospiraceae groups (phyla), but more in the Proteobacteria and Actinobacteria groups (phyla). In addition, a decrease in a butyrate-producing bacterium, which is important in intestinal health, has been observed in patients with IBD. Therefore, researches around the world are exploring the efficacy and safety of FMT for UC patients2.<\/p>\n
Article Abstract 1:<\/span><\/strong><\/p>\n Fecal Microbiota Transplantation for Ulcerative Colitis: A Systematic Review and Meta-Analysis Twenty five studies (2 randomized controlled trials, 15 cohort studies, and 8 case studies) with 234 UC patients were included. Overall, 41.58% (84\/202) patients achieved clinical remission (CR) and 65.28% (126\/193) achieved clinical response. Among the cohort studies, the pooled estimate of patients who achieved CR and clinical response were 40.5% (95% CI 24.7%-58.7%), and 66.1% (95% CI 43.7%-83.0%). Most adverse events were slight and self-resolving. The analyses of gut microbiota in 7 studies showed that FMT could increase microbiota diversity and richness, similarity, and certain change of bacterial composition.<\/p>\n Article Abstract 2:<\/strong><\/span><\/p>\n Single Delivery of High-Diversity Fecal Microbiota Preparation by Colonoscopy Is Safe and Effective in Increasing Microbial Diversity in Active Ulcerative Colitis.<\/a> Recent trials suggest fecal microbiota transplantation (FMT) with repeated enemas and high-diversity FMT donors is a promising treatment to induce remission in ulcerative colitis.\u00a0Of the 20 patients enrolled in this study, 7 patients (35%) achieved a clinical response by week 4. Three patients (15%) were in remission at week 4 and 2 of these patients (10%) achieved mucosal healing. Three patients (15%) required escalation of care. No serious adverse events were observed. Microbiome analysis revealed that restricted diversity of recipients pre-FMT was significantly increased by high-diversity 2-donor FMP. The microbiome of recipients post-transplant was more similar to the donor FMP than the pretransplant recipient sample in both responders and nonresponders. Notably, donor composition correlated with clinical response.<\/p>\n","protected":false},"excerpt":{"rendered":" \u4ec0\u9ebc\u662f\u6f70\u760d\u6027\u5927\u8178\u708e Ulcerative Colitis\uff08UC\uff09\uff1f \u767c\u708e\u6027\u8178\u75c5Inflammatory Bowel Disease\uff08IBD\uff09\u53ef\u5206\u70ba\u5169\u7a2e\uff0c\u6f70\u760d\u6027\u5927\u8178\u708e Ulcerative colitis \u548c \u514b\u9686\u6c0f\u75c7Crohn’s disease\uff08CD\uff09\u3002UC\u60a3\u8005\u7684\u8178\u9053\u8178\u58c1\u8868\u9762\u4e0a\u6703\u5f62\u6210\u5fae\u5c0f\u7684\u6f70\u760d\uff0c\u9019\u4e9b\u6f70\u760d\u53ef\u80fd\u6703\u5728\u8178\u9053\u5167\u51fa\u8840\u6216\u6d41\u81bf\u3002\u60a3\u75c5\u521d\u671f\uff0c\u901a\u5e38\u65bc\u76f4\u8178\u548c\u4e0b\u7d50\u8178\u767c\u708e\uff0c\u4f46\u708e\u75c7\u53ef\u80fd\u6703\u5f71\u97ff\u6574\u689d\u7d50\u8178\u3002UC\u60a3\u8005\u7684\u6574\u689d\u5927\u8178\uff08\u76f4\u8178\u81f3\u7d50\u8178\uff09\u5167\u8178\u58c1\u90fd\u6703\u767c\u708e\u53ca\u5f62\u6210\u6f70\u760d\u3002\u800c\u708e\u75c7\u662f\u7576\u8eab\u9ad4\u9762\u5c0d\u53d7\u5275\u50b7\u6216\u523a\u6fc0\u7684\u53cd\u61c9\uff0c\u4e26\u53ef\u5c0e\u81f4\u767c\u7d05\uff0c\u816b\u8139\u548c\u75bc\u75db\u3002 \u5982\u4f55\u8a3a\u65b7\uff1f \u5982\u679c\u60a3\u8005\u60a3\u6709\u809a\u7009\u800c\u7cde\u4fbf\u4e2d\u5e36\u8840\u53ca\u8179\u90e8\u75bc\u75db\uff0c\u91ab\u751f\u4fbf\u6703\u521d\u6b65\u8a3a\u65b7\u70ba\u6f70\u760d\u6027\u5927\u8178\u708e\uff0c\u70ba\u78ba\u5b9a\u8a3a\u65b7\u60a3\u8005\u5c07\u88ab\u8981\u6c42\u9032\u884c\u8840\u6db2\u6aa2\u67e5\u3002\u800c\u4e14\u9700\u8981\u6642\u60a3\u8005\u5c07\u6703\u9032\u884c\u5927\u8178\u93e1\u6aa2\u67e5\u53ca\u6d3b\u7d44\u7e54\u5316\u9a57\u4f86\u78ba\u8a3a\u3002 \u70ba\u4ec0\u9ebc\u9078\u64c7\u4eba\u985e\u83cc\u7fa4\u79fb\u690d\u7642\u6cd5 Human Microbiota Transplant\uff08HMT\uff09\u4f86\u8212\u7de9 \u6f70\u760d\u6027\u5927\u8178\u708eUlcerative Colitis (UC) \u6709\u95dc\u7684\u75c7\u72c0\uff1f \u767c\u708e\u6027\u8178\u75c5\uff08IBD\uff09\u60a3\u8005\u7684\u8178\u9053\u83cc\u7fa4\u6703\u6709\u6301\u7e8c\u6027\u7684\u8b8a\u5316\u3002\u7576\u8178\u9053\u83cc\u7fa4\u9054\u5230\u6700\u9ad8\u6c34\u5e73\uff0c\u9019\u6a23\u6703\u4f7f\u8178\u9053\u83cc\u7fa4\u591a\u6a23\u6027\u4e0b\u964d\uff0c\u8b8a\u6210\u5931\u8861\u72c0\u614b\uff08\u7a31\u70ba\u83cc\u7fa4\u5931\u8abfdysbiosis\uff09\u3002HMT\u6cbb\u7642UC\u5df2\u7d93\u5728\u4e00\u4e9b\u7814\u4e2d\u7522\u751f\u4e86\u6b63\u9762\u7684\u7d50\u679c\u3002\u5728\u4e00\u4efd\u7684\u7814\u7a76\u5831\u544a\u4e2d\uff0c555\u540dUC\u60a3\u8005\u4e2d\u6709201\u4f4d\uff08\u7d0436\uff05\uff09\u63a5\u53d7HMT\u6cbb\u7642\u5f8c\u7372\u5f97\u81e8\u5e8a\u4e0a\u7684\u8212\u7de9\uff0c\u800c\u672a\u80fd\u89c0\u5bdf\u5230\u6709\u660e\u986f\u7684\u526f\u4f5c\u7528\u3002\u57282017\u5e74\uff0c\u6fb3\u6d32\u767c\u5e03\u4e86\u4e00\u9805\u6700\u65b0\u7684\u7814\u7a76\uff0c\u7814\u7a76\u4e2d\u6307\u51faUC\u60a3\u8005\u63a5\u53d7FMT\u4e2d\uff0c\u670927\uff05\u7684\u60a3\u8005\u53d7\u76ca\uff0c\u800c \u63a5\u53d7\u5b89\u6170\u5291\u7684\u60a3\u8005\u53ea\u670911\uff05\u53d7\u76ca1\u3002 \u4ec0\u9ebc\u662f\u9999\u6e2fHMT\u8a08\u5283 ? 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\n<\/a>PLoS One<\/a><\/span>. 2016; 11(6): e0157259.\u00a0<\/span>Published online 2016 Jun 13. <\/span>doi:\u00a0 10.1371\/journal.pone.0157259<\/a><\/span><\/p>\n
\nInflamm Bowel Dis. 2017 Jun;23(6):903-911. doi: 10.1097\/MIB.0000000000001132.<\/a><\/p>\n